非A非B型慢性肝炎にヌ寸するインターフェロン投与の有効性に関する検討

概要

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We have treated 74 patients with chronic non-A, non-B hepatitis by interferon every day for 4-8 weeks or three times weekly for 12 or 24 weeks. All patients had liver biopsies before treatment. Fourteen of them had second biopsies within 2 weeks after treatment and 26 of them at 6 months after treatment. Liver biopsies were evaluated by means of Histology Activity Index (HAI) score. In the histology of pre-treatment, complete responders had lower numerical scores in the two categories of HAI: periportal necrosis and fibrosis, than no responders. Between pre- and posttreatment liver biopsies, periportal necrosis and intralobular inflammation significantly regressed.<BR>Most of patients had improvement of total scores of HAI when second biopsies were performed at the end of treatment. Furthermore, treatment for 12 or 24 weeks had improved total scores for longer tim than treatment for 4-8 weeks.
社団法人日本肝臓学会の論文