混合性結合織病の経過中に原発性胆汁性肝硬変症を合併した1症例

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A forty-eight-year old Japanese woman with mixed connective tissue disease (MCTD) who developed primary biliary cirrhosis (PBC) during the course is reported. She complained of fever, polyarthralgia and Raynaud's phenomenon thirteen years ago and was admitted to the Kyushu University Hospital. Anti-RNP antibody was positive while anti-Sm antibody was negative. She was diagnosed as MCTD and had been taking prednisolone. Two months before the second admission serum alkaline phosphatase level has gradually increased and the patient was readmitted to our hospital.<BR>Anti-mitochondrial antibody was positive. Biopsy of the liver disclosed non-supprative destructive cholangitis and the patients was diagnosed as stage I of PBC. Coincidence of the both diseases is very rare but it is interesting that PBC occurred during the course of MCTD. Some common immunological disorder may be attributed to the occurrence of the diseases.
社団法人日本肝臓学会の論文