A型肝炎におけるIgA型抗体の動態

概要

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The determination of IgA-type antibody against hepatitis A antigen (IgA-type HA antibody) was carried out in 65 sera from 13 patients with hepatitis A by a modified method using anti-IgA coated beads instead of anti-IgM ones in the HAVAB-M kit (Dainabot Co.). The serum IgA-type HA antibody was already detected within 1 week after the onset of symptoms, with maximum levels being observed at approximately 3 weeks after the onset, and then it decreased gradually. These findings were similar to the changes of IgM-type HA antibody, but IgA-type HA antibody was still detectable at 18 weeks after the onset.<BR>In addition, IgA-type antibody in sera proved to be a dimeric form of serum IgA separated by high speed liquid chromatography.<BR>From these results, it was strongly suggested that the intestinal mucosa could play an important role as a major source of serum IgA-type HA antibody at the early stage of HA virus infection.
社団法人日本肝臓学会の論文