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The molecular polymorphism of IgA molecules was analyzed by high speed liquid chromatography, and changes in the proportion of dimeric and monomeric IgA were investigated with regard to sera from normal controls and patients with liver cirrhosis, and to the specific IgA-type antibodies against lactalbumin (L-Alb).<BR>The molecular form of IgA in sera from normal controls mainly consisted of monomeric IgA with an average proportion of 82%, while its proportion of dimeric IgA was 18%. On the other hand, an increased proportion of dimeric IgA was observed in sera from patients with liver cirrhosis with an average of 32%. The IgA-type antibodies against L-Alb in sera from patients with liver cirrhosis showed 55% of the dimeric form, whose proportion was found to be significantly increased compared to that of serum IgA.<BR>From these results, the molecular polymorphism of IgA in sera appears to, partially, depend on the production of IgA in the gut-associated lymphoid tissues, and, at the same time, on the catabolism of IgA in the liver.
社団法人日本肝臓学会の論文