血清 type III procollagen aminopeptide の測定による肝線維化診断の試み

概要

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Serum type III procollagen aminopeptide (Pro (III)-N-P) was measured by radioimmunoassay in patients with various liver diseases. To evaluate the diagnostic significance of serum Pro (III)-N-P with special reference to hepatic fibrosis, the correlation of serum Pro (III)-N-P with histology obtained by needle liver biopsy was examined. Compared to normal controls (8.3±2.6ng/ml (mean±SD), n=32), serum level of Pro (III)-N-P was significantly evevated in patients with acute hepatitis (11.9±2.9ng/ml, n=5), chronic active hepatitis (14.9±5.0ng/ml, n=14), cirrhosis (18.1±4.7ng/ml, n=6), and alcoholic liver diseases (16.9±9.0ng/ml, n=27), but not in fatty liver and chronic persistent hepatitis. Serum Pro (III)-N-P showed close correlation with the degree of portal fibrosis in patients with nonalcoholic chronic liver diseases (r=0.64, n=24, P<0.001) and alcoholic liver diseases (r=0.53, n=25, p<0.01), and also closely related with the degree of pericellular fibrosis in case of alcoholic liver diseases (r=0.56, n=21, p<0.01), while other clinical tests showed poor correlation with hepatic fibrosis. Measurement of serum Pro (III)-N-P could be an useful parameter of hepatic fibrosis.
社団法人日本肝臓学会の論文