Survey of hepatobilary diseases in Sjoegren's syndrome. A clinicopathological study.:A clinicopathological study

概要

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Sjögren's syndrome (SS) is occasionally reported in patients with hepatobiliary diseases such as chronic hepatitis and primary biliary cirrhosis. However, the incidence and type of hepatobiliary diseases in patients with SS has not fully been evaluated. We surveyed hepatobiliary diseases in 162 patients with SS and found that 15 patients with SS disclosed hepatic dysfunction without any hepatitis B virus markers or history of excessive alcohol intake and blood transfusion. The pathological study of liver biopsies from 14 patients revealed 4 with chronic persistent hepatitis, 5 with chronic active hepatitis and 5 with primary biliary cirrhosis. Abnormal salivary gland lesions were found in 11 of 13 patients with SS and hepatic dysfunction, whereas they were found in 50 of 103 patients with SS without hepatic injury (p<0.025). Anti-hepatitis C virus associated antibody (HCV-Ab) was positive in 5 of 6 patients with chronic persistent hepatitis or active hepatitis, and negative in all 3 patients with primary biliary cirrhosis examined. The optical density values of HCV-Ab in 4 of the 5 HCV-Ab positive patients were more than 3.0. These findings suggest that the greater part of chronic hepatitis associated with SS might be caused by infection of hepatitis C virus in Japan, and that primary biliary cirrhosis might be the most likely complication of SS.
日本臨床免疫学会の論文