PAP法を用いた人肝におけるIgAとsecretory componentの検討--原発性胆汁性肝硬変を中心に

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Distribution of secretory component (SC) and IgA was examined by peroxidase-antiperoxidase method in normal livers and livers of chronic inactive hepatitis, chronic active hepatitis, liver cirrho-sis, extrahepatic cholestasis (EHC) and primary biliary cirrhosis (PBC). SC and IgA were demon-strated in the hepatocytes as well as in the intrahepatic bile duct epithelium. SC and IgA were found in the hepatocytes of considerable numbers of livers examined, irrespective of liver diseases, and dis-tribution of IgA was relatively widespread compared to SC. SC was found in the epithelium of the intrahepatic bile duct of any size; among which large sized duct epithelium was apt to be stained positively to more degree and extent than smaller one in any livers. The duct epithelium of the livers with EHC and PBC also revealed much more intensely and widespread positive staining of SC, com-pared with that of the other liver diseases. Electronmicroscopical observation of the livers with EHC and PBC showed that rough endoplasmic reticulum and the Golgi apparatus were hyperplastic. Dis-tribution of IgA in the biliary tree, in which positive epithelium was much more in larger sizes, was irregular and inconstant compared with that of SC, but relatively diffuse in livers with PBC and EHC. <BR>As to PBC livers, SC and IgA were widely distributed and intensely stained in the intrahepatic bile ducts with CNSDC changes as well as non-CNSDC changes, except the eithelium of a few normal appearing bile ducts and severely damaged bile ducts. It seemed likely that inflammatory changes of the intrahepatic bile ducts in PBC or EHC livers might promote an increase in degree and extent of the intra-epithelial SC production and IgA deposition, although exact nature of the two proteins remain unknown.
社団法人日本肝臓学会の論文

PAP法を用いた人肝におけるIgAとsecretory componentの検討--原発性胆汁性肝硬変を中心に

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