Clinico-pathological study in three patients with asymptomatic primary biliary cirrhosis for whom ursodeoxycholic acid was very effective.

概要

論文の詳細を見る
Three cases of asymptomatic primary biliary cirrhosis (a-PBC), for whom ursodeoxycholic acid (UDCA) was very effective, were studied clinico-pathologically. UDCA was given at a dose of 600mg per day in each patient, and given for 12 months in case 1, 6 months in case 2 and 5 months in case 3. Histologically, case 1 was in stage III, case 2 in stage III, and case 3 in stage I. In the biochemical data, all of three patients demonstrated the improvement in their serum levels of ALP, <SUB>γ</SUB>GPT and IgM. The titer of AMA fell obviously in one of them (case 1). In the histological study, it was demonstrated that infiltration of inflammatory cells in the portal tract and the portal enlargement were significantly improved, and that chronic non-suppurative destructive cholangitis was improved in common with all of three patients. In one of them (case 1), it was demonstrated that piecemeal necrosis was markedly improved. These findings suggest that not only biochemical data but also histological basic lesion of PBC may be improved due to UDCA administration. Consequently, it is suggested that UDCA may be very effective treatment for a-PBC.
社団法人日本肝臓学会の論文