Adjunctive Effects of Cyclosporine and Macrolide in Rapidly Progressive Cryptogenic Organizing Pneumonia with no Prompt Response to Steroid
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概要
- 論文の詳細を見る
Cryptogenic organizing pneumonia (COP) generally responds well to corticosteroids with a favorable outcome. However, it can rapidly worsen and lead to respiratory failure that is refractory to corticosteroids. Adjunctive drugs have been used in refractory cases with various outcomes, but treatment experience is still lacking. We present a case of rapidly progressive COP accompanying air leak syndrome, which showed no prompt response to corticosteroids alone but gradual improvement with the addition of cyclosporine and macrolide. This case report supports the existing literature suggesting that an early therapeutic trial of this drug combination might be considered in COP patients whose condition worsens despite corticosteroid administration.
著者
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Cha Seung
Department Of Ceramic Engineering Yonsei University
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Jung Tae
Department Of Internal Medicine Kyungpook National University Hospital
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Kim Chang
Department Of Biochemistry University Of Oxford
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Park Tae
Department Of Biological Science Korea Advanced Institute Of Science And Technology
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Park Jae
Department of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, South Korea
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Lee Jaehee
Department of Internal Medicine, Kyungpook National University, School of Medicine, South Korea
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Park Jae
Department of Internal Medicine, School of Medicine, Kyungpook National University, Korea
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