Combined Impact of the Association between Prepregnancy Body Mass Index and Gestational Weight Gain on the Placental/Umbilical Cord Blood Volume Collected

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概要

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• Placental/umbilical cord blood (CB) contains multipotent hematopoietic stem/progenitor cells and has been utilized worldwide both clinically and experimentally. Neonatal birth weight is positively correlated with CB volume and with the total number of nucleated cells associated with engraftment and survival after CB transplantation. Considering the recent increase in the frequency of low birth weight (<2500 g) and the decline in body mass index (BMI) among Japanese women of childbearing age, the present study investigated the combined impact of the prepregnancy BMI and the gestational weight gain on CB volume. From 1998 to 2007, CB samples were obtained from 579 healthy women with singleton vaginal deliveries. The prepregnancy BMI was classified into the underweight, normal, overweight, or obese groups. According to the current gestational weight gain recommendations or other new optimum recommendations, the gestational weight gain was classified into below, within, or above recommendations in each prepregnancy BMI group. The neonatal weight and placental weight had significantly positive effects on the CB volume. Underweight pregnant women demonstrated significantly lower neonatal and placental weight. According to the current recommendations, no significant difference in the CB volume was observed. According to the new optimum recommendations for underweight pregnant women, a significantly higher CB volume was obtained from the group within the recommended weight gain range than from the group below the recommended range. In the underweight group, a higher CB volume could be obtained if the upper limit of the gestational weight gain increases by a few kilograms more than the current gestational weight gain recommendations.

• 公益社団法人　日本薬学会の論文

著者

• TAKAHASHI Kenji

  Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences

• KASHIWAKURA Ikuo

  Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences

• OMORI ATSUKO

  Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Gra

• MANABE MAMI

  Department of Obstetrics and Gynecology, Hirosaki National Hospital

• Manabe Mami

  Department Of Obstetrics And Gynecology Hirosaki National Hospital

• Takahashi Kenji

  Dep. Of Radiological Life Sciences Hirosaki Univ. Graduate School Of Health Sciences

• Takahashi K

  School Of Life Sciences Tokyo Univ. Of Pharmacy And Life Sciences

• Takahashi Kayoko

  Central Research Lnstitute Meiji Milk Products Co. Ltd.

• Takahashi Kenji

  Department Of Orthopaedics Graduate School Of Medical Science Kyoto Prefectural University Of Medici

• Takahashi K

  Tokyo Univ. Agriculture And Technol. Tokyo Jpn

• Kashiwakura Ikuo

  Department Of Radiological Life Sciences Division Of Medical Life Sciences Hirosaki University

• Tanaka Kanako

  Department of Biology, Faculty of Science, Toyama University

• Tanaka Kanako

  Department Of Biology Faculty Of Science Toyama University

• Omori Atsuko

  Division Of Medical Life Sciences Department Of Radiological Life Sciences Hirosaki University Gradu

• Chiba Takako

  Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Gra

• Chiba Takako

  Division Of Medical Life Sciences Department Of Radiological Life Sciences Hirosaki University Gradu

• Takahashi Kenji

  Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo

• Takahashi Kenji

  Department Of Atomic Science And Nuclear Engineering Faculty Of Engineering Hokkaido University

• Takahashi Kenji

  Laboratory Of Molecular Biochemistry School Of Life Science Tokyo University Of Pharmacy And Life Sc

• Takahashi Kenji

  Department Of Applied Biological Chemistry Graduate School Of Agriculture Kinki University

• TANAKA Kanako

  Department of Obstetrics and Gynecology, Hirosaki National Hospital

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