Differential Induction from X-irradiated Human Peripheral Blood Monocytes to Dendritic Cells

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概要

• 論文の詳細を見る

• Dendritic cells (DCs) are a type of antigen-presenting cell which plays an essential role in the immune system. To clarify the influences of ionizing radiation on the differentiation to DCs, we focused on human peripheral blood monocytes and investigated whether X-irradiated monocytes can differentiate into DCs. The non-irradiated monocytes and 5 Gy-irradiated monocytes were induced into immature DCs (iDCs) and mature DCs (mDCs) with appropriate cytokine stimulation, and the induced cells from each monocyte expressed each DC-expressing surface antigen such as CD40, CD86 and HLA-DR. However, the expression levels of CD40 and CD86 on the iDCs derived from the 5 Gy-irradiated monocytes were higher than those of iDCs derived from non-irradiated monocytes. Furthermore, the mDCs derived from 5 Gy-irradiated monocytes had significantly less ability to stimulate allogeneic T cells in comparison to the mDCs derived from non-irradiated monocytes. There were no significant differences in the phagocytotic activity of the iDCs and cytokines detected in the supernatants conditioned by the DCs from the non-irradiated and irradiated monocytes. These results suggest that human monocytes which are exposed to ionizing radiation can thus differentiate into DCs, but there is a tendency that X-irradiation leads to an impairment of the function of DCs.

• 日本放射線影響学会の論文
• 2008-05-16

著者

• TAKAHASHI Kenji

  Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences

• KASHIWAKURA Ikuo

  Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences

• Yoshino Hironori

  Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Gra

• Monzen Satoru

  Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Gra

• Takahashi Kenji

  Dep. Of Radiological Life Sciences Hirosaki Univ. Graduate School Of Health Sciences

• Takahashi K

  School Of Life Sciences Tokyo Univ. Of Pharmacy And Life Sciences

• Takahashi Kayoko

  Central Research Lnstitute Meiji Milk Products Co. Ltd.

• Takahashi Kenji

  Department Of Orthopaedics Graduate School Of Medical Science Kyoto Prefectural University Of Medici

• Takahashi K

  Tokyo Univ. Agriculture And Technol. Tokyo Jpn

• Yoshino Hironori

  Department Of Physics And Electronics Faculty Of Engineering Osaka Prefecture University

• Kashiwakura Ikuo

  Department Of Radiological Life Sciences Division Of Medical Life Sciences Hirosaki University

• Takahashi Ken-ichi

  Department Of Industrial Chemistry Faculty Of Engineering Chiba Institute Of Technology

• Kashiwakura Ikuo

  Dep. Of Radiological Life Sciences Hirosaki Univ. Graduate School Of Health Sciences

• Takahashi Kyoko

  Department Of Food Science And Nutrition School Of Human Environmental Sciences Mukogawa Women'

• Kageyama T

  Kyoto Univ. Aichi Jpn

• Takahashi Kenji

  School Of Life Sciences Tokyo University Of Pharmacy And Life Sciences

• Takahashi Kenji

  Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo

• Kashiwakura Ikuo

  Graduate School Of Health Sciences Hirosaki University

• Takahashi Kenji

  Department Of Atomic Science And Nuclear Engineering Faculty Of Engineering Hokkaido University

• Takahashi Kenji

  Laboratory Of Molecular Biochemistry School Of Life Science Tokyo University Of Pharmacy And Life Sc

• Kashiwakura Ikuo

  北海道薬科大学 放射薬品

• Takahashi Kenji

  Department Of Applied Biological Chemistry Graduate School Of Agriculture Kinki University

• Yoshino Hironori

  Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences

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