Activation of C-Kit by Stem Cell Factor Induces Radioresistance to Apoptosis through ERK-dependent Expression of Survivin in HL60 Cells
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概要
- 論文の詳細を見る
We investigated the effect of SCF, a c-kit ligand, on the radiosensitivity of HL60 cells. X-ray-induced apoptosis in HL60 cells was significantly lower in the presence of SCF than in the absence of SCF. This attenuation of X-ray-induced apoptosis by SCF was abolished by PD98059 (an ERK inhibitor), but not by wortmannin (a PI3-K inhibitor) or GF109203X (a PKC inhibitor). The expression of phospho-ERK1/2 (active form) and the ERK1/2-regulated expression of survivin were found to increase in cells treated with X irradiation and SCF. However, X irradiation alone induced down-regulation of the expression of phospho-ERK1/2. Our findings suggest that activation of c-kit by SCF confers radioresistance through up-regulation of ERK-dependent survivin expression in HL60 cells.
- 日本放射線影響学会の論文
著者
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KASHIWAKURA Ikuo
Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences
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浅沼 武敏
北海道大学大学院獣医学研究科環境獣医科学講座放射線学教室
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KUWABARA MIKINORI
Laboratory of Radiation Biology, Graduate School of Veterinary Medicine
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INANAMI Osamu
Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of
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Kashiwakura Ikuo
Department Of Radiological Life Sciences Division Of Medical Life Sciences Hirosaki University
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Kuwabara Mikinori
弘前大学 保健学研究科放射線生命科学
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Kuwabara Mikinori
Laboratory Of Radiation Biology Graduate School Of Veterinary Medicine
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Kuwabara Mikinori
Laboratory Of Radiation Biology Department Of Environmental Veterinary Sciences Graduate School Of V
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Asanuma Taketoshi
Laboratory Of Radiation Biology Department Of Environmental Veterinary Sciences Graduate School Of V
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Asanuma Taketoshi
Laboratory Of Radiation Biology Department Of Environmental Veterinary Medicine Graduate School Of V
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Asanuma Taketoshi
Depertment Of Radiation Biology Faculty Of Veterinary Medicine Hokkaido University
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Inanami Osamu
Laboratory Of Radiation Biology Department Of Environmental Veterinary Medical Sciences Graduate Sch
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Inanami Osamu
Laboratory Of Radiation Biology Graduate School Of Veterinary Medicine Hokkaido University
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TAKAHASHI Momoko
Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of
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HAMASU Taku
Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of
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KUWABARA Mikinori
Labs. Radiat. Biol.
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Hamasu Taku
Laboratory Of Radiation Biology Department Of Environmental Veterinary Sciences Graduate School Of V
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Kuwabara M
Hokkaido Univ. Sapporo Jpn
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Kashiwakura Ikuo
Dep. Of Radiological Life Sciences Hirosaki Univ. Graduate School Of Health Sciences
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Kuwabara Mikinori
Lab. Radiat. Biol. Grad. Sch. Vet. Med. Hokkaido Univ.
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HOSSEINIMEHR Seyed
Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of
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Takahashi Momoko
Laboratory Of Radiation Biology Department Of Environmental Veterinary Sciences Graduate School Of V
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Hosseinimehr Seyed
Laboratory Of Radiation Biology Department Of Environmental Veterinary Sciences Graduate School Of V
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Jalal Hosseinimehr
Laboratory Of Radiation Biology Department Of Environmental Veterinary Sciences Graduate School Of V
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Kashiwakura Ikuo
Graduate School Of Health Sciences Hirosaki University
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Kashiwakura Ikuo
北海道薬科大学 放射薬品
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