The Promoting Activity on Human Megakaryocytopoiesis and Thrombopoiesis by Liquid Crystal-Related Compounds
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概要
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The liquid crystal compounds have a common structure with the cell membrane, having both a hydrophilic and hydrophobic residue, thus suggesting an affinity to the cell membrane. However, little information regarding a biological effect by liquid crystal compounds has been reported. In order to view the biological potential of liquid crystal compounds, the present study evaluated the in vitro human hematopoietic promoting effects by 18 liquid crystal-related compounds. In particular, these compounds are evaluated regarding their potential for platelet production from mature megakaryocytes by the culturing of CD34+ cells derived from normal human peripheral blood. Often, in the case of severe thrombocytopenia there is no choice but to perform a transfusion of platelet concentrates. Three of the tested compounds promoted megakacyocyte generation in the culture stimulated with thrombopoietin alone. In addition, two compounds led to a significant increase in CD42a+ particles which seemed to be platelets. At the same time, interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF), that were used as a positive control for in vitro megakaryocytopoiesis and thrombopoiesis, resulted in a dramatic increase in the total number of cells; however, their promoting activity on in vitro hematopoiesis was almost at a similar level with the compounds. These results suggest that some liquid crystal-related compounds have a promoting effect on human thrombopoiesis, and that these compounds act with a different mechanism from either IL-3 or GM-CSF since the compounds specifically stimulated thrombopoiesis. The liquid crystal compounds may therefore be useful to develop a new functional medicine or a medical application.
- 公益社団法人 日本薬学会の論文
著者
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TAKAHASHI Kenji
Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences
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KASHIWAKURA Ikuo
Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences
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Monzen Satoru
Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Gra
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YOSHIZAWA Atsushi
Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki Univ
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TERASAWA Rie
Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki Univ
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Miura Tomisato
Department Of Medical Technology Hirosaki University School Of Health Sciences
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Miura Tomisato
Department Of Bacteriology Hirosaki University School Of Medicine Hirosaki University
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Terasawa Rie
Department Of Frontier Materials Chemistry Graduate School Of Science And Technology Hirosaki Univer
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Takahashi Kenji
Department Of Orthopaedics Graduate School Of Medical Science Kyoto Prefectural University Of Medici
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Kashiwakura Ikuo
Department Of Radiological Life Sciences Division Of Medical Life Sciences Hirosaki University
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Yoshizawa Atsushi
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Fukushi Yukako
Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki Univ
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Takahashi Kenji
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
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Takahashi Kenji
Department Of Atomic Science And Nuclear Engineering Faculty Of Engineering Hokkaido University
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Takahashi Kenji
Department Of Applied Biological Chemistry Graduate School Of Agriculture Kinki University
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Monzen Satoru
Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences
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Fukushi Yukako
Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University
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