Novel Acridine-Based N-Acyl-homoserine Lactone Analogs Induce Endoreduplication in the Human Oral Squamous Carcinoma Cell Line SAS
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概要
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The cytotoxicity of novel acridine-based N-acyl-homoserine lactone (AHL) analogs was investigated on the human oral squamous carcinoma cell line SAS. One analog induced G2/M phase arrest at 5.3–10.6 µM and induced polyploidy at a higher dose (21.2 µM). Importantly, treatment of SAS cells with a combination of the AHL analog and the Jun N-terminal kinase (JNK) inhibitor, SP600125, prevented mitosis and induced polyploidy. The AHL analog synergized with X-irradiation to inhibit clonogenic survival of SAS cells; however, its radiosensitizing effects were relative to not X-irradiation-induced apoptosis but mitotic failure following enhanced expression of Aurora A and B. These results suggest that the active AHL analog showed growth-suppressive and radiosensitizing effects, which involve polyploidy followed by G2/M accumulation and atypical cell death in the SAS cell line.
著者
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Kashiwakura Ikuo
Department Of Radiological Life Sciences Division Of Medical Life Sciences Hirosaki University
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Suga Hiroaki
Research Center For Advanced Science And Technology The University Of Tokyo
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Hosokawa Yoichiro
Department Of Dental Radiology School Of Dentistry Health Sciences University Of Hokkaido
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Chai Hongbo
Department of Radiological Life Sciences, Graduate School of Health Sciences, Hirosaki University
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Hazawa Masaharu
Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences
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Igarashi Jun
Research Center for Advanced Science and Technology, The University of Tokyo
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Kashiwakura Ikuo
Department of Radiological Life Sciences, Graduate School of Health Sciences, Hirosaki University
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