Effects of Local and Whole Body Irradiation on Appearance of Osteoclasts During Wound Healing of Tooth Extraction Sockets in Rats
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概要
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We examined effects of local and whole body irradiation before tooth extraction on appearance and differentiation of osteoclasts in the alveolar bone of rat maxillary first molars. Wistar rats weighting 100g were divided into three groups: non-irradiation group, local irradiation group, and whole body irradiation group. In the local irradiation group, a field made with lead blocks was placed over the maxillary left first molar tooth. In the whole body irradiation group, the animals were irradiated in cages. Both groups were irradiated at 8 Gy. The number of osteoclasts around the interradicular alveolar bone showed chronological changes common to non-irradiated and irradiated animals. Several osteoclasts appeared one day after tooth extraction, and the maximal peak was observed 3 days after extraction. Local irradiation had no difference from non-irradiated controls. In animals receiving whole body irradiation, tooth extraction one day after irradiation caused smaller number of osteoclasts than that 7 day after irradiation during the experimental period. Whole body-irradiated rats had small osteoclasts with only a few nuclei and narrow resorption lacunae, indicating deficiency of redioresistant osteoclast precursor cells. Injection of intact bone marrow cells to whole body-irradiated animals immediately after tooth extraction recovered to some content the number of osteoclasts. These findings suggest that bone resorption in the wound healing of alveolar socket requires radioresistant, postmitotic osteoclast precursor cells from hematopoietic organs, but not from local sources around the alveolar socket, at the initial phase of wound healing.
- 日本放射線影響学会の論文
- 2007-07-15
著者
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Sakakura Yasunori
Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido
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Yajima T
北海道医療大学 口腔解剖
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Yajima Toshihiko
Department Of Oral Anatomy Higashi-nippon-gakuen University School Of Dentistry
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Yajima Toshihiko
Department Of Dental Radiology School Of Dentistry Health Sciences University Of Hokkaido
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Kaneko Masayuki
Department Of Dental Radiology School Of Dentistry Health Sciences University Of Hokkaido
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Sakakura Yasunori
Department Of Oral Anatomy School Of Dentistry Health Sciences University Of Hokkaido
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HOSOKAWA Yoichiro
Department of Radiological Life Sciences, Division of Medical Life sciences, Hirosaki University
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TANAKA Likinobu
Department of Dental Radiology, Health Sciences University of Hokkaido School of Dentistry
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Tanaka Likinobu
Department Of Dental Radiology School Of Dentistry Health Sciences University Of Hokkaido
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OKUMURA Kazuhiko
Department of Oral Surgery, School of Dentistry, Health Sciences University of Hokkaido
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Kaneko Masayuki
Department Of Dental Radiology Health Sciences University Of Hokkaido
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Hosokawa Yoichiro
Department Of Radiological Life Sciences Division Of Medical Life Sciences Hirosaki University
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Okumura Kazuhiko
Div. Of Reconstructive Surgery For Oral And Maxillofacial Region Dep. Of Human Biology And Pathophys
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Okumura Kazuhiko
Department Of Oral Surgery School Of Dentistry Health Sciences University Of Hokkaido
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Hosokawa Yoichiro
Department Of Dental Radiology School Of Dentistry Health Sciences University Of Hokkaido
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Sakakura Yasunori
Department Of Dental Radiology School Of Dentistry Health Sciences University Of Hokkaido
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Sakakura Y
Department Of Oral Anatomy School Of Dentistry Health Sciences University Of Hokkaido
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Kaneko Masayuki
Department of Cardiology, Cardiovascular Center, Oita Oka Hospital
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