<ORIGINAL>Appearance and distribution of osteoclast precursors and the morphological change during mouse mandibular osteogenesis

概要

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The appearance and distribution of osteoclast precursors and the morphological change of the precursors were examined during mouse mandibular osteogenesis, using enzyme histochemistry of tartrate-resistant acid phosphatase (TRAPase). Osteogenic tissue was not observed in the prospective region of the mandibles at embryonic day 12 (E12), but TRAPase-positive cells often existed in the region. Immature osteoblasts were seen as a population in E13 mandibles, and a thin layer of bone matrix had been formed at the central part of the osteogenic region in E14 mandibles. A number of TRAPase-positive osteoclast precursors were tandemly localized along the region. At these stages, the TRAPase-positive cells were oval and round in the vicinity of blood vessels, but at an earlier stage of the osteogenesis, the positive cells extended long processes towards the interspace between the osteoblasts. The present results demonstrated the morphology characteristic of the TRAPase-positive osteoclast precursors during osteoclast differentiation, suggesting the possibility that there is a cell-cell interaction between the osteoclast precursors and the osteoblasts in vivo.
北海道医療大学の論文
1998-12-30