Immunohistochemical Localization of Calcitonin Receptor in Mouse Tibiae
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概要
- 論文の詳細を見る
We have raised specific antisera against the extracellular domain of the rat/mouse calcitonin receptor (CTR), consequently immunolocalizing the CTR-positive cells in mouse tibiae. As expected, the immunoreactivity for the CTR was intensely detected in cells identical to tartrateresistant acid phosphatase (TRAP) positive multinucleated osteoclasts and mononuclear cells, whereas no immunoreactivity was detected in osteoblasts and bonemarrow cells. Most osteoclasts on the bone surface possessed the CTR, therefore indicating that bone resorbing osteoclasts could be prompted to respond to endogenous calcitonin. Immuno-electron microscopy revealed CTR-immunoreactivity mainly on the plasma membranes including the pits associated with the cell membranes, and sometimes on intracellular translucent vacuoles and in the vesicles in the vicinity of the Golgi apparatus in the osteoclasts. These results lead to the postulation that CTR is chiefly localized to the cell surface of osteoclast, but is subjected to continuous internalization followed by the receptor-transport to the Golgi apparatus.
- 日本組織細胞化学会の論文
著者
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Sakakura Yasunori
Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido
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Yajima T
北海道医療大学 口腔解剖
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AMIZUKA Norio
Center for Transdisciplinary Research, Niigata University
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Ozawa Hidehiro
Institute for Dental Science, Matsumoto Dental University
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Amizuka N
Center For Transdisciplinary Research Niigata University
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Amizuka Norio
First Department Of Oral Anatomy Niigata University School Of Dentistry
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IRIE Kazuharu
First Department of Oral Anatomy, Health Sciences University of Hokkaido, School of Dentistry
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Izumi Naoya
First Department of Oral Anatomy and Niigata University Faculty of Dentistry
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Yajima Toshihiko
Department Of Dental Radiology School Of Dentistry Health Sciences University Of Hokkaido
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Izumi Naoya
First Department Of Oral And Maxillofacial Surgery Niigata University:first Department Of Oral Anato
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Misumi Y
Fukuoka Univ. School Of Medicine Fukuoka Jpn
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Irie Kazuharu
Department Of Oral Anatomy School Of Dentistry Health Sciences University Of Hokkaido
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Irie Kazuharu
First Department Of Oral Anatomy Niigata University School Of Dentistry
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Ozawa Hidehiro
Institute For Dental Science Matsumoto Dental University
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Ozawa H
Institute For Oral Science Graduate School Of Oral Medicine Matsumoto Dental University
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Sakakura Yasunori
Department Of Oral Anatomy School Of Dentistry Health Sciences University Of Hokkaido
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Sasakura Yasunori
First Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido
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Yajima Toshihiko
First Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido
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Sakakura Yasunori
Department Of Dental Radiology School Of Dentistry Health Sciences University Of Hokkaido
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Sakakura Y
Department Of Oral Anatomy School Of Dentistry Health Sciences University Of Hokkaido
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Sakakura Yasunori
First Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido
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