Determination of Hippuric Acid in Urine by GC/MS: : in vivo Metabolism of Toluene to Hippuric Acid on Toluene Poisoning
スポンサーリンク
概要
- 論文の詳細を見る
This paper describes the use of the stable isotope tracer method for the metabolism from toluene to hippuric acid to help an assessing biological monitoring at low level exposure of toluene. This analytical method was applied to Wistar rats with poisoning of toluene during two weeks period, and was used to determine the urinary levels of endogeneous hippuric acid-d0 and exogenous hippuric acid-d5 which is produced from toluene-d8 in vivo, after intra-peritoneal administration of toluene-d8. It was possible to detect an alteration in the excretion of urinary hippuric acid compared with the control using deuterium-labeled toluene as a stable isotope tracer to distinguish its metabolite from endogeneous metabolite. We suggest that the in vivo metabolic investigation of the biological monitoring for hippuric acid should be based on the stable isotope method, and that the method was effective for the measurement of low exposure concentrations.
- 日本質量分析学会の論文
著者
-
Akamatsu Takashi
Department Of Applied Microbial Technology Faculty Of Biotechnology And Life Science Sojo University
-
Gunshin Hiromi
Department Of Preventive Medicine School Of Medicine University Of Ryukyus
-
Todoriki Hidemi
Department Of Environmental And Preventive Medicine Faculty Of Medicine School Of Medicine Universit
-
HAYASHI Tokishi
National Institute of Neuroscience, National Center of Neurology and Psychiatry
-
IIDA Yoshio
Department of Engineering, Seikei University
-
Dominicus Dalmas
Department of Preventive Medicine, School of Medicine, University of the Ryukyus
-
Todoriki Tatsuya
Department of Public Health, Faculty of Hygienic Science, Kitasato University
-
Akamatsu Takashi
Department of Preventive Medicine, School of Medicine, University of the Ryukyus
-
Gunshin Hiromi
Department of Preventive Medicine, School of Medicine, University of the Ryukyus
関連論文
- Functional replacement of yeast flavocytochrome b_2 with bacterial L-lactate dehydrogenase(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Estimation of Trans Fatty Acid Intake in Japanese Adults Using 16-Day Diet Records Based on a Food Composition Database Developed for the Japanese Population
- Analysis of p53 and K-Ras Gene Mutations in Patients with Chronic Bronchitis Using Laser Capture Microdissection Microscope and Mutation Detection
- Incorporation of the Whole Chromosomal DNA in Protoplast Lysates into Competent Cells of Bacillus subtilis
- Risk Factors for Cigarette Smoking Among High School Students in Okinawa, Japan
- Relationship of Food Intake and Dietary Patterns with Blood Pressure Levels Among Middle-Aged Japanese Men
- Relationship of Occupation to Blood Pressure Among Middle-Aged Japanese Men : The Significance of The Differences in Body Mass Index and Alcohol Consumption
- Drinking Habit as a Base for Blood Pressure Elevation : Difference in Epidemiological Significance by Beverage Type
- Effect of Calcium on the Zinc Uptake by Brush Border Membrane Vesicles Isolated from the Rat Small Intestine(Food & Nutrition)
- Lactose-enhanced Uptake of Calcium by Isolated Brush Border Membrane Vesicles from the Rat Small Intestine(Food & Nutrition)
- The Need for High Priorities in Preventive Health Care Administrations in Both Developed and Developing Countries
- Genetic Mapping and Properties of Filamentous Mutations in Bacillus subtilis(Microbiology & Fermentation Industry)
- CLINICAL STUDIES UPON ALTERATIONS OF HUMORAL FACTORS IN IMPENDING AND IMMEDIATE POST-MYOCARDIAL INFARCTION STAGE : Myocardial Infarction : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CLINICAL STUDIES UPON ALTERATIONS OF HUMORAL FACTORS IN IMPEDING AND IMMEDIATE POST-MYOCARDIAL INFARCTION STAGE : Cardiac Metabolism : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- Accumulation of a Recombinant Aspergillus oryzae Lipase Artificially Localized on the Bacillus subtilis Cell Surface
- GROWTH HORMONE RESPONSE TO GASTRECTOMY
- A Simple and Rapid Extraction of High Molecular Weight Chromosomal DNA from Bacillus subtilis Protoplasts for Cosmid Cloning and Interspecific Transformation
- Simple Detection of Xylosidase Activity in Single Colonies, Using 1-Naphthyl-β-D-xylopyranoside
- A Simple Assay for Xylanase Using o-Nitrophenyl-β-D-xylobioside
- Cytokine Profiles in Airways of Rats Exposed to Toluene Diisocyanate
- 511 Nucleotide sequence of a gene affecting the autolysin level and flagellation in Bacillus subtilis
- Role of ComFA in controlling the DNA uptake rate during transformation of competent Bacillus subtilis(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Potassium Excretion in Healthy Japanese Women Was Increased by a Dietary Intervention Utilizing Home-Parcel Delivery of Okinawan Vegetables
- Cytokine Production by Splenocytes and Thymocytes in Mice after Intranasal Exposure to Toluene Diisocyanate
- The Effects of Post-War Dietary Change on Longevity and Health in Okinawa
- Determination of 1,2,3,4-Tetrahydro-β-carboline and 1-Methyl-1,2,3,4-tetrahydro-β-carboline in Human Urine by Capillary GC/NICIMS
- Determination of Hippuric Acid in Urine by GC/MS: : in vivo Metabolism of Toluene to Hippuric Acid on Toluene Poisoning
- Successive Protoplast Transformation of Bacillus subtilis by Plasmid DNA under Low Concentration of Lysozyme
- DNA Taken into Bacillus subtilis Competent Cells by Lysed-Protoplast Transformation Is Not ssDNA but dsDNA(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Fate of Transforming Bacterial Genome Following Incorporation into Competent Cells of Bacillus subtilis : a Continuous Length of Incorporated DNA(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- S-6 A Review of Aging from the Aspect of Physiological Anthropology (Proceedings of the 42nd Meeting of Japan Society of Physiological Anthropology)
- A Preface to The Discussions in Gender Difference
- An Assessment of the Antimicrobial Activity of Commercially Avaliable Disinfectants
- Perspective Future of Physiological Anthropology in View of Health and Medical Sciences
- A Simple and Rapid Method for Intra-and Interspecific Transformation of Bacillus subtilis on Solid Media by DNA in Protoplast Lysates
- Interspecific Transformation of Bacillus subtilis Competent Cells by Chromosomal DNA in Lysates of Protoplasts of Bacillus amyloliquefaciens
- Essential involvement of the Bacillus subtilis ABC transporter, EcsB, in genetic transformation of purified DNA but not native DNA from protoplast lysates(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Determination of Kynurenine in Human Plasma by Gas Chromatography/Negative Ion Chemical Ionization Mass Spectrometry
- Effective Derivatization of Phenylalanine, Tyrosine and Related Compounds in Negative Ion Chemical Ionization Mass Spectrometry
- Effective Derivatization of Indole Compounds in Negative Ion Chemical Ionization Mass Spectrometry
- Role of ComEA in DNA uptake during transformation of competent Bacillus subtilis(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Plasmid transformation of competent Bacillus subtilis by lysed protoplast DNA(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- A simple assay for 6-aminohexanoate-oligomer-hydrolase using N-(4-nitrophenyl)-6-aminohexanamide(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Molecular orbital studies on the relative sensitivity and the nature of the fragmentation from molecular ion of some biologically important compounds for analytical application of negative ion chemical ionization mass spectrometry.
- Role of ComEA in DNA uptake during transformation of competent Bacillus subtilis
- Within- and Between-Individual Variation in Energy and Nutrient Intake in Japanese Adults: Effect of Age and Sex Differences on Group Size and Number of Records Required for Adequate Dietary Assessment
- Plasmid transformation of competent Bacillus subtilis by lysed protoplast DNA
- Ethanol production from D-lactic acid by lactic acid-assimilating Saccharomyces cerevisiae NAM34-4C(BREWING AND FOOD TECHNOLOGY)
- EFFECT OF ABDOMINAL SURGERY ON GLUCOSE TOLERANCE, PLASMA LEVELS OF INSULIN AND GLYCOGENIC AMINO ACIDS
- An Improved Method of Protoplast Regeneration for Bacillus Species and Its Application to Protoplast Fusion and Transformation
- Isolation and characterization of a mutant recombinant Saccharomyces cerevisiae strain with high efficiency xylose utilization(ENVIRONMENTAL BIOTECHNOLOGY)
- Potent L-lactic acid assimilation of the fermentative and heterothallic haploid yeast Saccharomyces cerevisiae NAM34-4C(ENVIRONMENTAL BIOTECHNOLOGY)
- Within- and Between-Individual Variation in Energy and Nutrient Intake in Japanese Adults : Effect of Age and Sex Differences on Group Size and Number of Records Required for Adequate Dietary Assessment
- Improvement of Ethanol Production from D-Lactic Acid by Constitutive Expression of Lactate Transporter Jen1p in Saccharomyces cerevisiae