Determination of Kynurenine in Human Plasma by Gas Chromatography/Negative Ion Chemical Ionization Mass Spectrometry
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概要
- 論文の詳細を見る
A sensitive method was developed for the determination of deuterated and non-deuterated kynurenine, one of the major metabolites of tryptophan, using gas chromatography/negative ion chemical-ionization mass spectrometry. Kynurenine was prepurified with an AG 50W × 2 cation-exchange column and then converted to pentafluoropropionyl-methyl-derivative. It was isolated and determined by selected ion monitoring (SIM). This method was applied to measurements of deuterated and non-deuterated kynurenine in human plasma after oral administration of L-tryptophan-2, 4, 5, 6, 7-d5.
- 日本質量分析学会の論文
著者
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HAYASHI Tokishi
National Institute of Neuroscience, National Center of Neurology and Psychiatry
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IIDA Yoshio
Department of Engineering, Seikei University
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Naruse Hiroshi
National Center For Nervous Mental And Muscular Disorders
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Mataga Nobuko
National Institute of Neuroscience
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Naruse Hiroshi
National Institute of Neuroscience
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Hayashi Tokishi
National Center for Nervous, Mental and Murcular Disorders
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Hayashi Tokishi
National Institute of Neuroscience
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