Effective Derivatization of Indole Compounds in Negative Ion Chemical Ionization Mass Spectrometry

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概要

• 論文の詳細を見る

• Hunt et al. went on to show considerable increases in negtive ion currents relative to positive ion currents for compounds with high electron affinity. In order to use the negative ion chemical ionization (NICI) mass spectrometry for metabolic studies of tryptophan and its metabolites, basic investigation were carried out to examine the usefulness of TFA- or PFP-derivatization in NICI mass spectrometry. As a result, these derivatization was confirmed to be very effective with respect to enhancing sensitivity, favorable fragmentation and other practical characteristics.

• 日本質量分析学会の論文

著者

• HAYASHI Tokishi

  National Institute of Neuroscience, National Center of Neurology and Psychiatry

• IIDA Yoshio

  Department of Engineering, Seikei University

• Hayashi T

  National Inst. Neuroscience Ncnp Tokyo Jpn

• Naruse Hiroshi

  National Center For Nervous Mental And Muscular Disorders

• Kamada Satoru

  National Center for Nervous, Mental and Murcular Disorders

• Daishima Shigeki

  Department of Engineering, Seikei University

• Kuzuya Masayuki

  Gifu College of Pharmacy

• Okuda Takachiyo

  Gifu College of Pharmacy

• Naruse Hiroshi

  National Center for Nervous, Mental and Murcular Disorders

• Hayashi Tokishi

  National Center for Nervous, Mental and Murcular Disorders

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