Inhibition of Increases in Blood Glucose and Serum Neutral Fat by Momordica charantia Saponin Fraction
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概要
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Focusing on a functional component of Momordica charantia, saponin, we investigated its effects on serum glucose and neutral fat levels. Saponin was extracted as a butanol-soluble fraction (saponin fraction) from hot blast-dried Momordica charantia powder. The disaccharidase-inhibitory activity and the pancreatic lipase-inhibitory activity of the saponin fraction were measured, and in vivo sugar- and lipid-loading tests were performed. The saponin fraction inhibited disaccharidase activity and elevation of the blood glucose level after sucrose loading. The fraction also markedly inhibited pancreatic lipase activity and elevation of the serum neutral fat level after corn oil loading. Based on these findings, the main active component related to the anti-diabetic effect of Momordica charantia is present in the butanol fraction, and it may be saponin. The blood glucose and serum neutral fat-lowering effects of Momordica charantia were closely associated with its inhibitory activity against disaccharidase and pancreatic lipase.
- 社団法人 日本農芸化学会の論文
著者
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OISHI Yuichi
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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UDAGAWA Haruhide
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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TANIGUCHI Hironobu
Department of Nutrition, Food Science & Culinary Arts, Toita Women's College
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TAKITA Toshichika
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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SAKAMOTO Tatsuaki
Department of Materials Science and Engineering, Graduate School of Engineering, Osaka University
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OZAWA Yoshio
Department of Health and Nutrition, Takasaki University of Health and Welfare
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Oishi Yuichi
Department Of Nutritional Science Faculty Of Applied Bioscience Tokyo University Of Agriculture
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KOBAYASHI-HATTORI Kazuo
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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