Calcitonin Gene-Related Peptide Upregulates Serum Amyloid A Synthesis through Activation of Interleukin-6
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概要
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We found that calcitonin gene-related peptide (CGRP) enhanced the expression of levels of serum amyloid A (SAA) and interleukin-6 (IL-6) in HepG2. In addition, CGRP-induced SAA1/2 mRNA expression was blocked by an anti-IL-6 neutralizing antibody in HepG2. These results suggest that CGRP promotes SAA synthesis through activation of IL-6 in human hepatocytes.
著者
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Oishi Yuichi
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
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KOBAYASHI-HATTORI Kazuo
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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YAMANE Takumi
Department of Nutritional Sciences, Faculty of Applied Bioscience, Tokyo University of Agriculture
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KOBAYASHI-HATTORI Kazuo
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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MATSUI Sho
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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