20922 骨髄細胞を用いた再生血管の拍動流負荷培養における周波数の効果(OS9 バイオエンジニアリング(4),オーガナイズドセッション)

概要

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Research to remodeling of tissue engineering (TE) vascular with culture of under a variety of dynamics conditions in recent at early stage is actively done, this research purpose is search for influence for structure formation and differentiation of TE vascular that had used mesenchymal stem cells (MSCs) that had differentiation ability to vascular cell in vitro . scaffold was made for outside diameter 7mm, lumen diameter 5mm, length 20mm and porosity 90% by using Poly-L-Lactic Acid. After scaffold where it seeded had static culture for 24hours, TE vascular was cultured under 3ways frequency (0.2, 1.0 and 2.0Hz) pulsatile flow at 1week. promotion of differentiation of MSCs into vascular cell and inhibition of cell growth because it loaded a high frequency pulsatile flow. Therefore, possibility of promotion of remodeling and induction of differentiation with frequency of pulsatile flow were suggested in remodeling TE vascular that had used MSCs in vitro.
一般社団法人日本機械学会の論文
2010-03-09