11603 コーンプレート型せん断応力負荷装置を用いた細胞ソーティングモデルの構築(バイオエンジニアリング,一般講演,学術講演)

概要

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Hematopoietic stem cells (HSCs) have the ability to renew themselves and the ability to differentiate all blood cell types. They play an important role in the treatment of leukemia. They are extracted from peripheral blood or bone marrow, however, the rate of HSCs is rare. So a system which extracts HSCs from peripheral blood or bone marrow efficiently and gently is required. We developed a cell sorting system using a cone-plate rheometer for extraction of rare cells from cell mixture. The separation principle of this system is based on specific adhesion by the antigen-antibody reaction between cells and antibody-coated plate. In this paper, we evaluated the performance of this cell sorting system.
社団法人日本機械学会の論文
2008-03-13