T0201-1-3 細胞膜微小変形が惹起するCa^<2+>上昇に対するPLC活性化の関与([T0201-1]細胞の構造と流れにおけるマイクロ・ナノスケール解析(1))

概要

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Mechanical stimulations induce Ca^<2+> increase, which could lead to several cellular destinies. This Ca^<2+> increase behaves intricately in spatio-temporal manner. In this study, involvement of PLC activation in mechanically stimulated Ca^<2+> increase in MDCK cells was investigated with real time dual imaging of Ca^<2+> increase and PLC activation. In mechanically stimulated cells, both Ca^<2+> increase and PLC activation were observed. However, in cells neighboring to mechanically stimulated cells, only Ca^<2+> increase was observed. These results indicate that PLC activation involve in Ca^<2+> increase in mechanically stimulated cells: however, PLC activation do not involve in Ca^<2+> increase in cells neighboring to mechanically stimulated cells.
一般社団法人日本機械学会の論文
2010-09-04