20302 拍動流による再生血管の3次元培養 : デバイスの開発と培養血管の評価(人工臓器と医用工学(1),OS.8 人工臓器と医用工学)

概要

論文の詳細を見る
Cells and tissues receive mechanical stimulation such as shear stress and stretching stress. It is known that these stimulation strongly influences the retention of their function. In developing vascular tissues, pulsatile flow culture, mimicking the biological environment, is known to increase the mechanical strength of the tissues and to promote the production of extracellular matrices. However, exisiting model of bioreactor which can give a mechanical stimulation to cells is very complicated. In this research, a new bioreactor was designed that can produce a circumstance such as in vivo and very simple. By using our original rapid formation model of tissue engineered vascular graft with collagen, the effect of mechanical stimulation was investigated.
社団法人日本機械学会の論文
2009-03-05