21103 再生血管の分化と力学特性に及ぼす力学刺激の効果(バイオエンジニアリング(1),OS3 バイオエンジニアリング)

概要

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Cells and tissue are always exposed to mechanical stimulation in vivo. This study investigated the effect of mechanical stimulation on tissue engineered vascular graft by culturing smooth muscle cells in PLLA scaffolds under rotational and pulsatile flow condition. Rupture strengths were significantly improved by pulsatile flow conditions. Histological staining indicated that mechanical stimulation facilitates cell proliferation and extracellular matrix generation. Immunohistochemistry for smooth muscle α-actin represented that tissue engineered vascular grafts cultured under pulsatile condition contain more redifferentiated smooth muscle cells than other culture conditions. These results demonstrate that pulsatile flow leads to restruction of extracellular matrix deposition and improvement of biomechanical functions toward the development of tissue engineered vascular graft.
社団法人日本機械学会の論文
2006-03-09