756 エレクトロスピニング法を用いた生分解性再生血管担体の開発(S01-3 細胞と組織のバイオメカニクス(3)-ミクロからマクロまで-,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

概要

論文の詳細を見る
Compliance mismatch between a native vessel and a artificial vascular graft causes low patency after several years of implantation. To develop a vascular scaffold having a mechanical characteristics like native vessels, a bi-layered tubular scaffold composed of a porous CLLA inner layer and PLLA fibrous outer layer using electrospinning technique was fabricated. A porous CLLA scaffold was inserted into mandrel-type collector having larger diameters than that of CLLA tubular scaffold. In addition, PLLA nanofibers were electrospun onto a pre-strained porous CLLA scaffold. In this study we researched relationships between wall thickness and each electrospinning conditions and effects of pre-straining on mechanical characteristics of fabricated multi-layered tubular scaffold.
社団法人日本機械学会の論文
2008-08-02