20919 スキャホールドフリーの再生血管構築(OS9 バイオエンジニアリング(4),オーガナイズドセッション)

概要

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Strength of tissue engineered(TE) vascular grafts depends on extracellular matrix(ECM) deposition derived from the cells. Scaffolds interfere with cell-cell interaction and ECM produced by the cells. Recently, fabrication methods of scaffold-free TE constructs have emerged. The goal of this study was to formulate scaffold-free TE blood vessel by using agarose wells. In order to develop scaffold-free TE blood vessel, the first purpose was to form tissue rings. Tissue rings with inner diameters of 2, 4 and 6mm were formed by seeding agarose wells with human umbilical mesenchymal stem cells(HUMSCs). The cells was cultured for 8days and 14days to form thick rings. The strength, modulus and toughness of the rings was compared to TE blood vessel by using scaffold of PLLA(Poly-L-Lactidc Acid). This system is a helpful tool to formulate scaffold-free TE blood vessel. By using methods of fabricating tissue rings, we aim scaffold-free TE blood vessel.
一般社団法人日本機械学会の論文
2010-03-09