J0203-3-4 高せん断マイクロ流路内流れにおける赤血球変形能の電気的計測(第2報)(医療診断のためのマルチスケール血流動態計測と解析(3))

概要

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A sensor which can efficiently and sequentially measure the deformability of a single red blood cell (RBC) flowing in a micro-channel is proposed in the present study. Counter-electrode-type micro membrane sensors are attached onto the channel bottom and the time-sequential data of the electric resistance is measured using an alternative current vs. voltage (I-V) method as the RBC passes between the electrodes. The RBC is deformed due to the high shear flow having the degree depending on its elastic modulus. Therefore the electrical profile is believed to represent the deformability of each cell. Experiment is carried out with the samples of normal human RBCs and glutaraldehyde-treated (rigidized) RBC together with the visualization measurements to evaluate the feasibility of the present method.
2009-09-12