腎微小循環に対するウワバインの急性効果

概要

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Renal clearance and micropuncture studies were carried out in anesthetized Sprague-Dawley rats to examine the acute effects of ouabain on the renal microcirculation and the tubuloglomerular feedback (TGF) mechanism. Ouabain infusion at 1.0 and 5.0 μg/kg/min had no effect on blood pressure. Infusion of the lower dose of ouabain did not affect any parameters in the clearance experiment or the TGF response. At the higher dose (5.0 μg/kg/min), however, renal vascular resistance and the filtration fraction increased significantly. Renal plasma flow tended to decrease, but GFR, urine volume, and urinary excretion of sodium remained unchanged. Micropuncture experiments revealed that at the higher dose the percentage reduction in early proximal flow rate in response to loop perfusion decreased significantly, indicating TGF inhibition and afferent arteriole dilatation. These results suggest that the administration of 5.0 μg/kg/min of ouabain causes simultaneous dilatation of the afferent arteriole and even greater contraction of efferent arteriole.
東京女子医科大学の論文
2001-06-25