Comparison of Structure and Antitumor Activity of Polysaccharides Isolated from Fukurotake, the Fruiting Body of Volvariella volvacea(Biological Chemistry)

概要

論文の詳細を見る
An α-linked D-manno-D-galactan, glycogen, and three kinds of branched (1→3)-β-D-glucans were isolated from Fukurotake, the fruiting body of Volvariella volvacea by successive extractions with cold and hot water, cold and hot alkali, and dimethyl sulfoxide. The mannogalactan, purified from the cold water extract, had a MW of 4 × 10^5, and consisted of an α-(1→6) .linked D-galactose backbone, one out of every three D-galactose residues being substituted with a single α-D-mannosyl group. The glycogen, isolated from the hot water extract, had a MW of 12x 10^5, and 14〜15 D-glucose residues as an average chain length, as revealed by methylation analysis. The α-(1→4)-linked unit chains of this glycogen were distributed from DP 6 to 13, approximately in equal numbers. There were three kinds of branched (1→3)-β-D-glucans, isolated from alkali and dimethyl sulfoxide extractions. They contain a backbone of (1→3)-linked D-glucose residues with side chains of single D-glucosyl groups, but having different degrees of branching. In addition, alkali-extracted glucans contain small but significant proportions of (1→6)-linked sugar units. Among these polysaccharides, the cold alkali-extracted glucan (degree of branching, 1:5) showed a potent antitumor activity against Sarcoma 180 solid tumors implanted in mice, and chemical modifications changed its original activity, confirming our previous results. Other polysaccharides, such as the mannogalactan and other (1→3)-β-D-glucans, showed no or lower antitumor activity.
社団法人日本農芸化学会の論文
1986-09-23

Comparison of Structure and Antitumor Activity of Polysaccharides Isolated from Fukurotake, the Fruiting Body of Volvariella volvacea(Biological Chemistry)

スポンサーリンク

概要

著者

関連論文

スポンサーリンク