Determination of Chlorpromazine, Thiamine, Lincomycin, Ofloxacin and Theophylline by Ternary Complex Formation with Eosin and Palladium(II)(Analytical,Chemical)

概要

論文の詳細を見る
Color reactions among a drug, an organic dye and a metal ion were studied, and a simple and sensitive spectrophotometric method, without solvent extraction, has been established for the. determination of some drugs by ternary complex formation with eosin and palladium(II) (probably involving an ion-association complex between (Pd^<II>(drug)_n) cation and eosin anion). Beer's law held up to ca. 2.0×10^<-5> M of each drug at 545nm in the final volume of 10ml, with apparent molar absorptivities of 5.7×10^4 1mol^<-1>cm^<-1> for chlorpromazine, 6.7×10^4 for thiamine, 5.5×10^4 for lincomycin, 4.0×10^4 for ofloxacin, and 3.5×10^4 for theophylline. The proposed method was applied to the determination of these drugs in pharmaceutical preparations. A fluorescence quenching method for the determination of these drugs by forming this ternary complex was also investigated for the purpose of enhancing the sensitivity of determination.
公益社団法人日本薬学会の論文
1987-12-25