Application of o-Hydroxyhydroquinonephthalein-Uranium (VI) Complex to Determination of Neomycin and Toburamycin

概要

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An application of o-hydroxyhydroquinonephthalein (Qn. Ph)-uranium (VI) [U (VI)] complex to the determination of neomycin (NM) and toburamycin (TOB) was developed. The spectrophotometric method is based on the fact that the absorption maximum of Qn. Ph.-U (VI)-NM or Qn. Ph.-U (VI)-TOB complex shows a red shift compared with that of Qn. Ph.-U (VI) complex and the magnitude of the increase in absorbance is proportional to the concentration of NM or TOB. This method could be used to determine 3-50μg/10ml of NM and 2-40μg/10ml of TOB ; the apparent molar absorptivities were 1.28×10^5 l mol^<-1>ccm^<-1> for NM and 1.17×10^5 l mol^<-1> cm^<-1> for TOB at 545nm. Recoveries of NM and TOB added to human urine and saliva were examined.
公益社団法人日本薬学会の論文
1984-03-25