o-スルホフェニルフルオロン-モリブデン(VI)との三元錯体の生成反応に基づくクロルプロマジン及びその関連薬物の吸光光度定量(<特集>若手研究者の初論文)

概要

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A novel spectrophotometric method was established for the determination of chlorpromazine (CPZ) and its related drugs. The method is based on ternary complex formation among o-sulfophenylfluorone, molybdenum(VI) and CPZ. In the determination of CPZ, Beer's law is obeyed in the range of 0.2〜7.0μg ml^<-1>. The effective molar absorptivity at 525nm and the relative standard deviation were 4.6×10^4 dm^3 mol^<-1>cm^<-1> and 2.4% (n=6), respectively. The method was successfully applied to assays of CPZ and its related drugs in pharmaceutical preparations. The proposed method, requiring no solvent extraction, should be useful for a simple and sensitive determination of CPZ and its related drugs.
社団法人日本分析化学会の論文
2006-09-05