Effect of a glycine residue insertion into crustacean hyperglycemic hormone on hormonal activity
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概要
- 論文の詳細を見る
Crustacean hyperglycemic hormone (CHH) and molt-inhibiting hormone (MIH) have similar amino acid sequences and therefore comprise a peptide family referred to as the CHH family. All MIHs unexceptionally have an additional glycine residue at position 12, which is lacking in all CHHs. In order to understand the relevance of the absence of the glycine residue for hyperglycemic activity, a mutant CHH having a glycine residue insertion was prepared, and its hyperglycemic activity was assessed. This mutant CHH had the same disulfide bond arrangement as the recombinant CHH produced in Escherichia coli cells, and exhibited a similar circular dichroism spectrum to the recombinant CHH, indicating that the two CHHs possessed similar conformations. The mutant CHH showed a hyperglycemic effect weaker than the recombinant CHH by about one order of magnitude. These results suggest that the insertion of a glycine residue is one of the indices for structural and functional divergence of the CHH family peptides.
- 社団法人日本動物学会の論文
- 2004-11-25
著者
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KATAYAMA Hidekazu
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Nagasawa Hiromichi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Nagasawa Hiromichi
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Katayama Hidekazu
Department Of Applied Biochemistry Institute Of Glycoscience Tokai University
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Katayama Hidekazu
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Katayama Hidekazu
Department Applied Of Biochemistry Tokai University
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