アスピリン・アスコルビン酸配合剤投与時の血漿中,白血球中アスコルビン酸量の動態

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It had been reported that the long-term administration of aspirin resulted in the decrease of vitamin C storage in the tissues. This is the basis for the addition of 25mg of ascorbic acid to enteric-coated 250mg aspirin tablet. The mixed preparation is currently used in Japan. The present study was undertaken to investigate the effect of this mixed preparation on the ascorbic acid concentrations in blood plasma and in leukocytes. Twelve healthy male student volunteers were divided into two groups of six each. One group was administered with the mixed preparation at a dose of 3 tablets t.i.d. (2.25g aspirin and 225mg vitamin C per day) for four days, while the other group received enteric-coated tablets containing only aspirin at the same dose of aspirin in a similar manner. The concentration of ascorbic acid in the plasma from the combined tablet-treated group increased to 143% of the initial level after 6 hours, being kept significantly higher than that of the group treated with only aspirin during the following four days. On the other hand, no significant increase in the leucocyte ascorbic acid level was noted after treatment with the combined tablets. This fact seemed to provide an evidence that the absorption of ascorbic acid into leukocyte was inhibited by salicylates because salicylates competed with ascorbic acid for the transport receptors in the leukocyte membrane, which had been indicated by the other authors. These results thus clearly indicated that the combined administration of aspirin with ascorbic acid resulted in a definite increase of the ascorbic acid concentration in plasma, and that the combined tablet was potentially useful to prevent the decrease of vitamin C storage which was seen after the long-term administration of aspirin.
北里大学の論文
1978-10-31

アスピリン・アスコルビン酸配合剤投与時の血漿中,白血球中アスコルビン酸量の動態

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