エンザイムイムノアッセイによる唾液中抗てんかん薬濃度測定法,および唾液中濃度と血中濃度との比率

概要

論文の詳細を見る
The widely used antiepileptic drugs, phenobarbital (PB) and diphenylhydantoin (DPH), in saliva could be determined with a slight modification of the enzyme immunoassay technique which was usually used to determine these drugs in plasma. This method was simple and rapid, and required small sample volume, less than 100 μl of saliva. Both saliva and plasma were collected at the same time from the epileptic patients to compare the drug concentration within each paired sample. The concentrations of these drugs in saliva correlated well with those in plasma. The mean of saliva/plasma ratio of PB was 0.374 (SD=0.095) and that of DPH was 0.105 (SD=0.022). The data show that these drug concentrations in saliva are similar to those of the pharmacologically active and free form in plasma, and that the monitoring of these drugs in saliva should be useful in the treatment of epileptic patients.
北里大学の論文
1977-12-31