Clinical Significance of Estrogens in Chronic Aggressive Hepatitis
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概要
- 論文の詳細を見る
In eight patients with chronic aggressive hepatitis during menopause after bilateral ovariectomy, the excretion of estrogens in the urine decreased; gonadotropin, especially follicular stimulating hormone, in the blood serum increased; and the maximum excretion of estrogen in urine after trial medication of estrone sodium sulfonate came on the following day and the excretion lasted 8 days with a tendency toward gradual decrease. In these patients, the inflammatory process came to a standstill both clinically and histologically after therapeutic medication of medicinal estriol for 6-9 weeks. In six patients during menopause after physiological climacterium, the excretion of estrogens in the urine decreased, except for estrogen excretions of 10μg a day several times a month. Follicular stimulating hormone in the blood serum increased in these patients, except for several times a month which were within the normal range. The excretion of estrogen in the urine after trial medication of estrone sodium sulfonate showed a similar pattern to that of the former group but the maximum excretion was lower. In these patients, the inflammatory process tended to come to a standstill clinically as well as histologically after therapeutic medication of medicinal estriol for 6-9 weeks. The PHA-test for estrogens and immunological investigations showed no pathological findings in either group. From these findings, it can be said that estrogen deficiencies influence pathogenesis and the clinical course of chronic aggressive hepatitis.
- 東海大学の論文
著者
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NISHIKAWA Hiroyuki
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University
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IWAMURA Kenichiro
Department of Internal Medicine III, School of Medicine, Tokai University
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Nishikawa Hiroyuki
Department Of Breast And Endocrine Surgery St. Marianna University School Of Medicine
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Nishikawa Hiroyuki
Department Of Internal Medicine School Of Medicine Tokai University
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Iwamura Kenichiro
Department Of Internal Medicine School Of Medicine Tokai University
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Iwamura Kenichiro
Department Of Internal Medicine Iii School Of Medicine Tokai University
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Nishikawa Hiroyuki
Department of Applied Physics and Chemistry, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan
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IWAMURA Kenichiro
Department of Internal Medicine, School of Medicine Tokai University
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