Anxiety-Like Behavior in Elevated Plus-Maze Tests in Repeatedly Cold-Stressed Mice
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概要
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To clarify the relationship between SART (specific alternation of rhythm in temperature) stress (repeated cold stress) and anxiety, the effects of various types of stress on the behavior of mice were studied in elevated plus-maze tests and then the effects of anxiolytics were evaluated. The percentage of time spent in the open arms of the plus-maze apparatus decreased in mice subjected to SART stress without change in the total number of arm entries. No change was noted in mice subjected to other stresses, such as 1-h, 2-day and 5-day cold stress and 1-h, 15-h and 5 × 15-h restraint stress. The reduction in the percentage of time spent in the open arms caused by SART stress was inhibited by single and repeated administrations of diazepam and alprazolam and by a single administration of buspirone, which have no influence on the percentage of time spent in the open arms in nonstressed mice, but not by flumazenil, WAY-100635 and chronic treatment with buspirone. The effects of diazepam and buspirone were antagonized by flumazenil and WAY-100635, respectively. The behavior of SART-stressed mice in the plus-maze would thus appear to arise from anxiety, to which benzodiazepine and serotonin receptors are related, but the diazepam binding inhibitor, an endogenous anxiogenic protein, is not. Thus SART-stressed animals may be useful for investigating the psychopharmacological and neuropharmacological basis of anxiety.
- 社団法人 日本薬理学会の論文
- 2001-02-01
著者
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NISHIKAWA Hiroyuki
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University
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Nojiri Hiroyuki
Graduate School Of Pure And Applied Sciences University Of Tsukuba
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Itoh Eiji
Department Of Pharmacology Faculty Of Pharmacy Kinki University
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Itoh Eiji
Department Of Bioresources Science Faculty Of Agriculture Kochi University
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Itoh E
Kochi Univ. Nankoku Jpn
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Hata Toshiyuki
Biotechnology Fukuyama University
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Nishikawa H
Graduate School Of Pure And Applied Sciences University Of Tsukuba
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Nishikawa H
Tokyo Metropolitan Univ. Tokyo Jpn
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Nishikawa H
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
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HATA Taeko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University
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FUNAKAMI Yoshinori
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University
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NISHIKAWA Hiroyuki
Graduate School of Pure and Applied Sciences, University of Tsukuba
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Nishikawa Hiroyuki
Graduate School Of Pure And Applied Sciences University Of Tsukuba
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Nishikawa Hiroyuki
Department Of Breast And Endocrine Surgery St. Marianna University School Of Medicine
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Hata Taeko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
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Funakami Yoshinori
Division Of Biochemistry Kinki University School Of Pharmacy
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Nishikawa Hiroyuki
Department of Applied Physics and Chemistry, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan
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Hata Taeko
Biotechnology, Fukuyama University
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