EFFECT OF GINSENG-20S-PROSAPOGENIN ON TISSUE BLOOD FLOW MEASURED BY THE HYDROGEN CLEARANCE METHOD IN SYMPATHICOTONIC- OR PARASYMPATHICOTONIC-TYPE STRESSED MICE
スポンサーリンク
概要
- 論文の詳細を見る
An attempt was made to investigate the preventive effects of 20S-prosapogenin (20S-PG), a partial hydrolyzate of diol saponins isolated from Panax ginseng, on changes of peripheral tissue blood flow in diseased model animals with vagotonic-type autonomic imbalance [SART (specific alternation of rhythm in temperature)-stressed (repeated coldstressed) mice developed by us], and sympathicotonic-type stressed mice [restraint and water immersion-stressed (RWIS) mice], using the hydrogen clearance method. Decreases in gastric blood flow in both body and pyloric regions of the stomach and increases in dermal blood flow in both the shoulder and lumbar region in SART-stressed mice were prevented to a considerable extent by daily treatments with 20S-PG, 2.5-10mg/kg/d. Similarly, the marked decrease in gastric blood flow following RWIS loading was significantly blocked by 10 mg/kg/d of 20S-PG. 20S-PG had a minor preventive effect on decreases in hepatic and dermal blood flow in RWIS mice. The preventive effect of 20S-PG on changes in tissue blood flow, recognized in model animals with autonomic imbalance not only in the vagotonic state but also in the sympathicotonic state, is therefore regarded with considerable interest and may provide a clue to explain the pharmacological action of ginseng.
- 公益社団法人日本薬学会の論文
著者
-
Itoh Eiji
Department Of Pharmacology Faculty Of Pharmacy Kinki University
-
Itoh Eiji
Department Of Bioresources Science Faculty Of Agriculture Kochi University
-
Itoh Eiji
Department Of Physical Electronics Tokyo Institute Of Technology:(present Address) Department Of Ele
-
Hata Toshiyuki
Biotechnology Fukuyama University
-
KAWABATA Atsufumi
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University
-
HATA Taeko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University
-
Kawabata Atsufumi
Department Of Pharmacology Faculty Of Pharmacy Kinki University
-
Hata Taeko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
-
Itoh E
Department Of Physical Electronics Tokyo Institute Of Technology:(present Address) Department Of Ele
-
KITA TOMITARO
Department of Pharmacology, Faculty of Pharmacy, Kinki University
-
KAWASHIMA YUJI
Central Research Laboratory, Yamanouchi Pharmaceuticals Co., Ltd.
-
Kita Tomitaro
Department Of Pharmacology Faculty Of Pharmacy Kinki University
-
Kawashima Yuji
Central Research Laboratory Yamanouchi Pharmaceuticals Co. Ltd.
-
Kawabata Atsufumi
Div. Of Pharmacology And Pathophysiology School Of Pharmacy Kinki Univ.
-
Hata Taeko
Biotechnology, Fukuyama University
関連論文
- Specific Alternation of Rhythm in Temperature (SART) Stress-Induced Irritable Bowel Syndrome-Like Changes in Mice and Effects of Drugs
- Current-Voltage Characteristics of Porphyrin/C60 Multi-Layered Organic Photovoltaic Device with and without Hole Collection Oxide Films
- Modulation of Capsaicin-Evoked Visceral Pain and Referred Hyperalgesia by Protease-Activated Receptors 1 and 2
- Characterization of Protease-Activated Receptors in Rat Peritoneal Mast Cells
- A Role for Corticotropin-Releasing Factor in Repeated Cold Stress-Induced Anxiety-Like Behavior during Forced Swimming and Elevated Plus-Maze Tests in Mice (Pharmacology)
- Anxiety-Like Behavior in Elevated Plus-Maze Tests in Repeatedly Cold-Stressed Mice
- Depressive State With Anxiety in Repeated Cold-Stressed Mice in Forced Swimming Tests
- Examination of in vitro Chemosensitivity Test Using Collagen Gel Droplet Culture Method with Colorimetric Endpoint Quantification
- Studies on the Variation in Clinical Laboratory Data and Safety Evaluation of Pharmaceuticals
- Physicochemical and Crystal Structure Analyses of the Antidiabetic Agent Troglitazone
- Physicochemical Analyses of Phase Transition and Dehydration Processes of a New Oral 1β-Methylcarbapenem Antibiotic Agent, CS-834
- Crystal stucture of a 1β-Methylcarbapenem Antibiotic, Pivaloyloxymethyl(1R, 5S, 6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[(R)-5-oxopyrolidin-3-yl]-1-carbapen-2-em-3carboxylate, CS-834 Dihydrate
- Lipase-Catalyzed Asymmetric Synthesis of Desprenyl-carquinostatin A and Descycloavandulyl-lavanduquinocin
- Effects of Some β-Adrenoceptor Antagonists on Orthostatic Hypotension in Repeatedly Cold-(SART-) Stressed Rats(Pharmacology)
- Effects of AF-DX116 and Other Muscarinic Receptor Antagonists on Orthostatic Hypotension in Autonomic Imbalanced (SART-Stressed) Rats
- In Situ Observation of the Four-step Dehydration Process of the 1β-Methylcarbapenem Antibiotic CS-834 Crystal by X-Rays
- The Absolute Configuration of (+)-Oxopropaline D by Theoretical Calculation of Specific Rotation and Asymmetric Synthesis
- Crystal Structure of an Antidiabetic Agent, (±)-5-[4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazollidine, Troglitazone Dihydrate
- Blood Pressure and Heart Rate Are Increased by AF-DX 116, a Selective M_2 Antagonist, in Autonomic Imbalanced and Hypotensive Rats Caused by Repeated Cold Stress
- Crystal and Molecular Structure of a 1β-Methylcarbapenem Antibiotic, CS-834
- Crystal and Molecular Structure of (±)-(5R)-[4-(6-Hydroxy-(2R)-2, 5, 7, 8-tetramethylchroman-2-ylmethoxy)benzyl] -2, 4-dioxothiazolidine Monohydrate
- Insecticidal Activity of α-Methylene-γ-butyrolactone against Several Insect Pests
- Precursor of α-Methylene-γ-butyrolactone Involved in the Insecticidal Activity of Thunberg Spiraea, Spiraea thunbergii
- Insecticidal Component in Thunberg Spiraea, Spiraea thunbergii, against Thrips palmi
- Photovoltaic Properties of Organic p-n Junction Devices Consisting of Phthalocyanine and n-Type Porphyrin Deposited on an n-Type TiO_2 Layer
- Effect of Lithium Perchlorate Doping and Prebiasing on Electrical Conduction of Molecularly Doped Poly (N-vinylcarbazole) Light Emitting Diode
- Ultraviolet Photoelectron Spectroscopy and Surface Potential of π-conjugated Langmuir-Blodgett Films on Gold Metal Electrode
- Electrostatic Phenomena in π-conjugated Langmuir-Blodgett Films on Metal Electrodes
- EFFECT OF GINSENG-20S-PROSAPOGENIN ON TISSUE BLOOD FLOW MEASURED BY THE HYDROGEN CLEARANCE METHOD IN SYMPATHICOTONIC- OR PARASYMPATHICOTONIC-TYPE STRESSED MICE
- PHARMACOLOGICAL ACTIONS OF GINSENG SAPONIN IN STRESS MICE
- EXPERIMENTAL PHARMACOLOGICAL STUDY ON PARTIAL SYMPATHICOTONIA IN RESTRAINT AND WATER IMMERSION STRESSED ANIMALS
- ANALGESIC AND OTHER PHARMACOLOGIC ACTIONS OF SAIKO-SAPONIN IN REPEATED COLD STRESSED (SART STRESSED) ANIMALS
- Protease-Activated Receptor (PAR), a Novel Family of G Protein-Coupled Seven Trans-membrane Domain Receptors: Activation Mechanisms and Physiological Roles
- DECREASE OF ACH RESPONSE IN ISOLATED DUODENUM FROM REPEATED COLD STRESSED (SART STRESSED) MICE
- Enhancement of the Open-Circuit Voltage and Hole Conduction of Tetraphenyl Porphyrin/C60 Multilayered Photovoltaic Device by the Insertion of Oxide Hole Collection Layers
- Capsazepine Inhibits Thermal Hyperalgesia but Not Nociception Triggered by Protease-Activated Receptor-2 in Rats
- Short-distance Walking Responses of Thrips palmi KARNY(Thysanoptera:Thripidae)to Tomato Leaves
- EFFECTS OF EXOGENOUS STIMULI AND CENTRALLY ACTING DRUGS ON GALVANIC SKIN RESPONSES IN RATS
- Field Emission from Carbon-Nanotube-Dispersed Conducting Polymer Thin Film and Its Application to Photovoltaic Devices
- Interfacial Electronic Phenomena and Capacitance -Voltage Characteristics of Phthalocyanine Langmuir-Blodgett Films
- Surface Potential of Polyimide Langmuir-Blodgett Films Induced by Photoirradiation
- Blood Coagulation and Fibrinolysis in SART-Stressed (Repeated Cold-Stressed) Rats and Drug Effects on the Altered Hemostatic Parameters
- Patterning of Polyimide/Single-Walled Carbon Nanotube Composite and Its Electrical Properties
- Regulatory Effect of Neurotropin on Nasal Mucosal Hypersensitivity in Guinea Pigs Caused by SART (Intermittent Exposure to Cold) Stress
- Mechanism of Hyperalgesia in SART Stressed (Repeated Cold Stress) Mice: Antinociceptive Effect of Neurotropin
- Analgesic Mechanism of Neurotropin: Relation to the Serotonergic System and Influence of Spinal Cord Transection
- Impairment of Passive Avoidance Performance in SART-Stressed Mice and the Action of Drugs
- The Abnormal Open-Field Behavior of SART-Stressed Rats and Effects of Some Drugs on It
- Changes in Platelet Count and Related Parameters in SART-Stressed Mice and the Action of Administered Neurotropin
- Changes of Tissue Blood Flow in Mice Loaded with SART (Repeated Cold) Stress or Restraint and Water Immersion Stress and the Effect of Administered Neurotropin
- Total Acetylcholine Content, and Activities of Choline Acetyltransferase and Acetylcholinesterase in Brain and Duodenum of SART-Stressed (Repeated Cold-Stressed) Rat
- STUDIES ON THE SITE OF ACTION OF NEUROTROPIN IN EXPERIMENTS ON DENERVATION-SUPERSENSITIVITY OF THE DUODENUM AND VAS DEFERENS OF RATS AND MICE
- EXPERIMENTAL PARTIAL SYMPATHICOTONIA, AND EFFECTS OF SOME DRUGS ON IT IN RESTRAINT AND WATER IMMERSION STRESSED ANIMALS
- Current-Voltage Characteristics of Porphyrin/C_ Multi-Layered Organic Photovoltaic Device with and without Hole Collection Oxide Films
- Calculation of the Surface Potential across Langmuir-Blodgett Films with Polar Molecules
- A Newly Designed Method for Removal of the Pineal Body, and Depression of Convulsions and Enhancement of Exploratory Movements by Pinealectomy in Mice
- DECREASE IN PAIN THRESHOLD IN SART STRESSED MICE
- Impact of a Pharmacist-Implemented Anemia Management in Outpatients with End-Stage Renal Disease in Japan(Biopharmacy)
- Field Emission from Carbon-Nanotube-Dispersed Conducting Polymer Thin Film and Its Application to Photovoltaic Devices
- Relationship between Work Function of Hole Collection Electrode and Temperature Dependence of Open-Circuit Voltage in Multilayered Organic Solar Cells
- Fabrication of Inverted Bulk-Heterojunction Organic Solar Cell with Ultrathin Titanium Oxide Nanosheet as an Electron-Extracting Buffer Layer
- Photovoltaic Properties of Bulk-Heterojunction Organic Solar Cell with Ultrathin Titanium Oxide Nanosheet as Electron Selective Layer
- Fabrication of Polymer-Based Transistors with Carbon Nanotube Source Drain Electrodes Using Softlithography Techniques
- Fabrication of Double Layered Hybrid Solar Cells Consisting of Low-Temperature Anatase Titanium Oxide and Conducting Polymer
- Photovoltaic Properties of Organic p–n Junction Devices Consisting of Phthalocyanine and n-Type Porphyrin Deposited on an n-Type TiO2 Layer
- Electrical Properties of Heat-Treated C60 Field Effect Transistor Prepared on Polyimide Gate Insulator
- A characteristic pattern of active avoidance behavior in SART-stressed rats.
- A POSSIBLE METABOLIC PATHWAY OF γ-GUANIDO- AND γ-GUANIDO-β-OXY-BUTYRIC ACID BY HETEROARGINASE
- ATTENUATIVE ANTIDOTAL EFFECTS OF GUANIDYL COMPOUNDS ON NH8 TOXICATION
- Changes of total acetylcholine content and the activity of related enzymes in SART (repeated cold)-stressed rat brain and duodenum.
- Electrocorticogram in rats loaded with SART stress (repeated cold stress).
- Photovoltaic Properties of Bulk-Heterojunction Organic Solar Cell with Ultrathin Titanium Oxide Nanosheet as Electron Selective Layer (Special Issue : Solid State Devices and Materials)
- Changes in CNS Levels of Serotonin and Its Metabolite in SART-Stressed(Repeatedly Cold-Stressed)Rats.
- Methacholine- and adrenaline-induced arrhythmias in repeatedly cold-stressed mice.
- Effect of Lithium Perchlorate Doping and Prebiasing on Electrical Conduction of Molecularly Doped Poly (N-vinylcarbazole) Light Emitting Diode
- Subsensitivity to substance P in SART-stressed mice.