Changes in CNS Levels of Serotonin and Its Metabolite in SART-Stressed(Repeatedly Cold-Stressed)Rats.
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概要
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Central nervous system levels of serotonin (5-HT) and 5-hydroxy-indoleacetic acid (5-HIAA) in SART (specific alternation of rhythm in temperature)-stressed (repeatedly cold-stressed) rats were examined by HPLC-ECD. In SART-stressed rats, the levels of both 5-HT and 5-HIAA decreased in many brain areas. In the spinal cord, only the 5-HT level decreased. Therefore, the ratio of 5-HIAA to 5-HT increased only in the spinal cord. These results suggest that SART-stressed rats have some form of abnormality in the synthetic system of 5-HT.
- 公益社団法人 日本薬理学会の論文
著者
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Itoh Eiji
Department Of Bioresources Science Faculty Of Agriculture Kochi University
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KAWABATA Atsufumi
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University
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Hata Taeko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
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