Capsazepine Inhibits Thermal Hyperalgesia but Not Nociception Triggered by Protease-Activated Receptor-2 in Rats

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概要

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• Protease-activated receptor-2 (PAR-2), expressed in sensory neurons, triggers thermal hyperalgesia, nociceptive behavior and spinal Fos expression in rats. In the present study, we examined if the nociceptive processing by PAR-2 is mediated by trans-activation of capsaicin receptors. The thermal hyperalgesia following an intraplantar (i.pl.) administration of the PAR-2-activating peptide SLIGRL-NH2 was completely abolished by the capsaicin receptor antagonist capsazepine. In contrast, neither the nociceptive behavior nor spinal Fos expression in response to i.pl. SLIGRL-NH2 were attenuated by capsazepine. Our data imply that trans-activation of capsaicin receptors by PAR-2 might be involved in the PAR-2-triggered thermal hyperalgesia, but not nociception.

• 社団法人 日本薬理学会の論文
• 2002-06-01

著者

• Itoh Hideki

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Kawabata Atsufumi

  近畿大学 薬学部生体機能病因解明学

• KAWABATA Atsufumi

  Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University

• KURODA Ryotaro

  Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University

• Kawabata Atsufumi

  Department Of Pharmacology Faculty Of Pharmacy Kinki University

• Kawabata Atsufumi

  Department Of Pathophysiology & Therapeutics Faculty Of Pharmaceutical Sciences Kinki University

• Kawao N

  Kinki Univ. Higashi‐osaka Jpn

• Kuroda R

  Division Of Physiology And Pathophysiology School Of Pharmaceutical Sciences Kinki University

• Kuroda Ryotaro

  Department Of Neurosurgery Kinki University Medical School

• KAWAO Naoyuki

  Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University

• SHIMADA Chiho

  Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University

• Itoh Hideki

  Department Of Anesthesiology And Critical Care Medicine Yokohama City University Graduate School Of

• Itoh Hideki

  Department Of Pathophysiology And Therapeutics School Of Pharmaceutical Sciences Kinki University

• Shimada Chiho

  Department Of Pathophysiology And Therapeutics School Of Pharmaceutical Sciences Kinki University

• Kawabata Atsufumi

  Div. Of Pharmacology And Pathophysiology School Of Pharmacy Kinki Univ.

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