Characterization of Protease-Activated Receptors in Rat Peritoneal Mast Cells
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概要
- 論文の詳細を見る
Activation of protease−activated receptor(PAR)−1 or PAR−2 elicits inflammation most probably via mast cell degranulation in vivo.The present study aimed at characterizing PARs in rat peritoneal mast cells(PMC).Messenger RNA for PAR−1, but not for PAR−2, was detected in PMC.Thrombin, the PAR−1 agonist SFLLR−NH2 or the PAR−2 agonist SLIGRL−NH2 failed to induce histamine release from PMC.Surprisingly, the PAR−2−inactive control peptide LSIGRL−NH2 triggered histamine release from PMC.Thus, PAR−1, but not PAR−2, are expressed in PMC, whereas neither PAR−1 nor PAR−2 are considered to be involved in degranulation of PMC.LSIGRL−NH2 does not appear to be appropriate as a control peptide for PAR−2 in inflammation studies.
- 社団法人 日本薬理学会の論文
- 2000-01-01
著者
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Kawabata Atsufumi
近畿大学 薬学部生体機能病因解明学
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Kawai Kenzo
Research & Development Center Fuso Pharmaceutical Industries Ltd
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NISHIKAWA Hiroyuki
Research & Development Center, Fuso Pharmaceutical Industries Ltd
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KAWABATA Atsufumi
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University
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KURODA Ryotaro
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University
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NISHIDA Minoru
Research & Development Center, Fuso Pharmaceutical Industries Ltd
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Kawabata Atsufumi
Department Of Pathophysiology & Therapeutics Faculty Of Pharmaceutical Sciences Kinki University
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Nishida M
Research & Development Center Fuso Pharmaceutical Industries Ltd
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Nishikawa H
Research & Development Center Fuso Pharmaceutical Industries Ltd
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Kuroda R
Division Of Physiology And Pathophysiology School Of Pharmaceutical Sciences Kinki University
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Kuroda Ryotaro
Department Of Neurosurgery Kinki University Medical School
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