Changes of total acetylcholine content and the activity of related enzymes in SART (repeated cold)-stressed rat brain and duodenum.
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概要
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In SART-stressed rats regarded as pathologically diseased model animals with vagotonic-type autonomic imbalance, a decrease of total acetylcholine (T-ACh) content and enhancements of choline acetyltransferase (CAT) and acetylcholinesterase (AChE) activities were recognized in the basal ganglia and hypothalamus. In contrast, in the duodenum, an increase in T-ACh content and a decrease in AChE activity were found, while CAT activity showed no change. These findings suggest that in both brain areas of basal ganglia and hypothalamus in SART-stressed rats, ACh neurons may be activated.
- 公益社団法人 日本薬理学会の論文
著者
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Itoh Eiji
Department Of Bioresources Science Faculty Of Agriculture Kochi University
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KAWABATA Atsufumi
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University
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Hata Taeko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
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Kita Tomitaro
Department Of Pharmacology Faculty Of Pharmacy Kinki University
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HIGASHIGUCHI Takashi
Department of Pharmacology Kinki University
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HIGASHIGUCHI Takashi
Department of Pharmacology, Faculty of Pharmacy, Kinki University
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