Effects of Some β-Adrenoceptor Antagonists on Orthostatic Hypotension in Repeatedly Cold-(SART-) Stressed Rats(Pharmacology)
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概要
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Rats stressed by specific alternation of rhythm in temperature (SART) show various symptoms of disautonomia, increased pulse rates, continuous hypotension, and severe orthostatic hypotension (OH) when they are subjected to postural change. The OH symptoms are improved by muscarinic M_2-receptor blockers. In the present study, effects of β-adrenoceptor blocking agents on OH in SART-stressed rats were investigated. Anesthetized rats were restrained on a board in the supine position, and direct blood pressure and ECG were measured automatically using Fluclet^[○!R] Jr.2. Postural change was performed by raising the rat's head up to a 60° angle for 4min. Unstressed rats treated with hexamethonium showed large decrease in blood pressure, small reflex from the bottom of pressure and decreased tachycardia reflex, whereas isoproterenol showed little changes. In SART-stressed rats, isoproterenol alleviated the decrease in blood pressure in postural change, brought large reflex from the bottom of pressure and increased tachycardia reflex, whereas hexamethonium had little changes. Propranolol and atenolol induced the similar changes as those seen by hexamethonium. ICI-118,551, a selective β_2-adrenoceptor antagonist showed large reflex from the bottom of pressure and increased tachycardia reflex in stressed rats, whereas little changes in unstressed rats. In conclusion, it was suggested that the hypotension in OH manifestation time of rats reflects the state of peripheral blood vessels, and β_1-adrenoceptors played a role in compensatory tachycardia reflex and β_2-adrenoceptors in blood pressure reflex. The circulatory regulation in SART-stressed rats seems to be poorly functioning in nervous reflex in postural changes.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
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Itoh Eiji
Department Of Pharmacology Faculty Of Pharmacy Kinki University
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Itoh Eiji
Department Of Bioresources Science Faculty Of Agriculture Kochi University
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Itoh E
Kochi Univ. Nankoku Jpn
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Hata Toshiyuki
Biotechnology Fukuyama University
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HATA Taeko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University
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FUNAKAMI Yoshinori
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University
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ITANO Seigo
Department of Pharmacology, Faculty of Pharmacy, Kinki University
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Itano Seigo
Department Of Pharmacology Faculty Of Pharmacy Kinki University
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Hata Taeko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
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Funakami Yoshinori
Division Of Biochemistry Kinki University School Of Pharmacy
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Hata Taeko
Biotechnology, Fukuyama University
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