Subsensitivity to substance P in SART-stressed mice.
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概要
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The sensitivity of SART-stressed (repeated cold-stressed) mice to substance P (SP) was studied. The behavioral responses to intrathecal SP in the stressed mice were less marked than those in non-stressed mice. The 50% effective dose of SP, however, did not differ between the 2 groups. Also, the antagonistic effect of intrathecal [D-Pro<SUP>2</SUP>, D-Trp<SUP>7, 9</SUP>]-substance P against SP was not different. These results suggest that SART-stressed mice are subsensitive to exogenous SP and that the number but not the affinity of SP receptors may be altered.
- 公益社団法人 日本薬理学会の論文
著者
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Itoh Eiji
Department Of Bioresources Science Faculty Of Agriculture Kochi University
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KAWABATA Atsufumi
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Kinki University
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Hata Taeko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
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Kita Tomitaro
Department Of Pharmacology Faculty Of Pharmacy Kinki University
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OYAMA Ritsuko
Department of Pharmacology, Faculty of Pharmacy, Kinki University
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