A Role for Corticotropin-Releasing Factor in Repeated Cold Stress-Induced Anxiety-Like Behavior during Forced Swimming and Elevated Plus-Maze Tests in Mice (Pharmacology)
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概要
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SART (specific alternation of rhythm in temperature) stress is known to cause anxiety-like behavior in mice/rats in several anxiety-related behavioral tests. In the present study, we investigated possible roles for corticotropin-releasing factor (CRF) and glucocorticoids in SART stress-induced anxiety-like behavior in two different anxiety-related behavioral tests. In the forced swimming test, CRF, administered intracerebroventricular (i. c. v. ) at 0.5-2 pmol/mouse, dose-dependently reduced immobility time in unstressed and SART-stressed mice. α-Helical CRT, a specific CRF receptor antagonist, administered i. c. v. at 0.1-1 nmol/mouse, dose-dependently increased immobility time in SART-stressed mice, but not in unstressed mice. In the elevated plus-maze test, CRF at 10-20 pmol/mouse significantly decreased the time spent in open arms in unstressed mice. CRF at a high dose tended to decrease this time in SART-stressed mice, but this decrease was not statistically significant. α-Helical CRF failed to modify the time in unstressed mice. In contrast, α-helical CRF at 0.38 and 0.75 nmol/mouse increased the time in SART-stressed mice. Both immobility time in the forced swimming test and time spent in open arms in the elevated plus-maze test in unstressed and SART-stressed mice were unaffected by adrenalectomy. These results suggest that CRF plays an important role in anxiety-like behavior caused by SART stress.
- 社団法人日本薬学会の論文
- 2004-03-01
著者
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NISHIKAWA Hiroyuki
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University
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Nojiri Hiroyuki
Graduate School Of Pure And Applied Sciences University Of Tsukuba
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Itoh Eiji
Department Of Pharmacology Faculty Of Pharmacy Kinki University
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Itoh Eiji
Department Of Bioresources Science Faculty Of Agriculture Kochi University
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Itoh E
Kochi Univ. Nankoku Jpn
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Hata Toshiyuki
Biotechnology Fukuyama University
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Nishikawa H
Graduate School Of Pure And Applied Sciences University Of Tsukuba
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Nishikawa H
Tokyo Metropolitan Univ. Tokyo Jpn
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Nishikawa H
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
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HATA Taeko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University
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FUNAKAMI Yoshinori
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University
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NISHIKAWA Hiroyuki
Graduate School of Pure and Applied Sciences, University of Tsukuba
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Nishikawa Hiroyuki
Graduate School Of Pure And Applied Sciences University Of Tsukuba
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Nishikawa Hiroyuki
Department Of Breast And Endocrine Surgery St. Marianna University School Of Medicine
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Hata Taeko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kinki University
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Funakami Yoshinori
Division Of Biochemistry Kinki University School Of Pharmacy
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Nishikawa Hiroyuki
Department of Applied Physics and Chemistry, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan
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Hata Taeko
Biotechnology, Fukuyama University
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