In Situ Observation of the Four-step Dehydration Process of the 1β-Methylcarbapenem Antibiotic CS-834 Crystal by X-Rays
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概要
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The 1β-methylcarbapenem antibiotic CS-834 takes six crystalline forms depending on ambient conditions. The X-ray powder diffraction revealed that the dihydrate crystal (B2-form) was changed to the monohydrate (B1-form) through the intermediate form (B2'-form). The monohydrate form was then changed to the dehydrate (B0-form) through the intermediate B1'-form. The progress of the dehydration along the needle axis (c-axis) was observed under a microscope. When a single crystal of the B2-form was mounted on a diffractometer and the humidity was reduced, the crystal was gradually changed to the various dehydration forms with retention of the single crystal. The crystals of B2- to B0-forms form isostructures to each other except the solvent water molecules. In the crystal structure of the B1-form, the pivaloyloxymethyl moiety is disordered. One is nearly similar to that of the B2-form, while another is similar to that of the B0-form. Each crystal structure consists of a columnar arrangement of CS-834 along the c-axis, and the water molecules are located between the columns and form a characteristic hydrogen bond network. When the water molecules leave the crystal, the columns slide slightly following the slight conformational change in the pivaloyloxymethyl groups and are connected by another type of hydrogen bond network. Such a rearrangement of the hydrogen bond network should be a motive force of the phase change to the next step due to the dehydration. Since the hydrogen bond network extends along the c-axis, the dehydration proceeds along the c-axis as observed microscopically.
- 公益社団法人日本薬学会の論文
- 2003-12-01
著者
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小林 匡子
東北薬科大学生薬学教室
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Kobayashi Kyoko
Tohoku Pharmaceutical University
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OHASHI Yuji
Department of Chemistry and Materials Science Tokyo Institute of Technology
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Ohashi Yuji
Laboratory Of Animal Science Kyoto Prefectural University:(present Address)laboratory Of Food Hygien
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Hata Toshiyuki
Biotechnology Fukuyama University
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KOBAYASHI Katsuhiro
Process Development Laboratories, Sankyo Co., Ltd.
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FUKUHARA Hiroshi
Process Development Laboratories, Sankyo Co., Ltd.
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HATA Tadashi
Biomedical Research Laboratories, Sankyo Co., Ltd.
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Fukuhara Hiroshi
Process Development Laboratories Sankyo Co. Ltd.
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Hata Tadashi
Biomedical Research Laboratories Sankyo Co. Ltd.
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Ohgo Y
Niigata College Of Pharmacy
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Hata Taeko
Biotechnology, Fukuyama University
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