Estimation of Amount of Total Tannins in Rhubarb and Chinese Medicinal Prescriptions Containing Rhubarb Using Mouse Amylase Inhibition Activity
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概要
- 論文の詳細を見る
Rhubarb and some Chinese medicinal prescriptions containing rhubarb inhibited the a-amylase activity in isolated mouse plasma. Phenolic constituents were found to be concerned with this action. The total amount of tannins in the rhubarb samples were measured by the RMB method, and their amylase inhibition activities correlated with the RMB values. This finding suggested that the concentration of total tannins in this crude drug can be estimated roughly by measuring amylase inhibition activity. The inhibitory activities also correlated with the ratio of rhubarb included in Chinese medicinal prescriptions. At present, qualitative and quantitative physicochemical analyses are the major methods of evaluating crude drugs and Chinese medicinal prescriptions. However, measuring amylase inhibitory action may be applicable to biological evaluation and quality control of these Pharmaceuticals derived from natural products.
- 日本生薬学会の論文
- 2005-06-20
著者
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小林 匡子
東北薬科大学生薬学教室
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Kobayashi Kyoko
Tohoku Pharmaceutical Univ. Miyagi Jpn
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Kobayashi Kyoko
Tohoku Pharmaceutical University
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Kaneko Mayumi
Tohoku Pharmaceutical University
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Yoshizaki Fumihiko
Tohoku College Of Pharmacy
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